We present a high-resolution modelling effort to investigate the possible end-of-century evolution of the main physical processes in the Adriatic Sea in a severe climate change scenario, with an ensemble approach (i.e. use of multiple simulations) allowing us to control the uncertainty of the predictions. Our model exhibits a satisfactory capability to reproduce the recent past and provides a basis for a set of multidisciplinary studies in this area over a multi-decadal horizon.