This research predicts the potential future of the Eastern Mediterranean's circulation under the RCP8.5 emission scenario, using a coupled regional climate system model and a global oceanic model. The study predicts a significant decrease in dense water formation, a key process in Mediterranean overturning circulation, by up to 84% in the Adriatic, Aegean, and Levantine seas by the end of the century. This study forecasts a shift in the main source of Eastern Mediterranean Deep Water from the Adriatic Sea to the Aegean Sea. These changes, related to increased vertical stratification that hinders vertical mixing and convection, fill a crucial gap in our understanding of how climate change could reshape the Mediterranean Sea's dynamics.